Uncover the hidden dangers of medications that may cause angioedema. Recognize the symptoms and seek prompt medical attention. Ensure your well-being. Proactively managing your health can help prevent serious complications.
What Causes Angioedema?
Angioedema is a swelling beneath the skin that can be caused by various factors, including certain medications, allergies, and genetics. In some cases, angioedema can also be a symptom of a more serious underlying medical condition.1
One of the most common causes of angioedema is an allergic reaction to certain substances, such as foods (e.g., nuts, shellfish, milk, and eggs), insect bites or stings, and medications (e.g., penicillin and aspirin). When an individual comes into contact with an allergen, their immune system overreacts and releases histamine and other chemicals, which cause blood vessels to leak fluid and lead to swelling.
Hereditary angioedema is a rare genetic condition that causes recurrent episodes of angioedema without an obvious trigger. It is caused by a deficiency or dysfunction of a protein called C1 esterase inhibitor, which is involved in regulating the immune system’s response.
Medications That Trigger Angioedema
Certain medications may also trigger angioedema as a side effect. Some of the medications commonly associated with angioedema include:
- Angiotensin-converting enzyme (ACE) inhibitors: These medications are commonly used to treat high blood pressure and heart failure. ACE inhibitors work by relaxing blood vessels and lowering blood pressure. However, they can also cause angioedema in some individuals.
- Non-steroidal anti-inflammatory drugs (NSAIDs): NSAIDs are commonly used to relieve pain, fever, and inflammation. Some examples of NSAIDs include ibuprofen, naproxen, and aspirin. Angioedema is a known side effect of NSAIDs, particularly in individuals with a history of allergies or asthma.
- Aspirin: Aspirin is a commonly used pain reliever and blood thinner. It can cause angioedema in some individuals, especially those with a history of aspirin sensitivity or asthma.
- Other medications: Angioedema has also been associated with certain antibiotics (e.g., penicillin and cephalosporins), blood pressure medications (e.g., calcium channel blockers and beta-blockers), and chemotherapy drugs.
Seek Medical Attention for Angioedema
Angioedema can be a serious condition, especially if it affects the airway and causes difficulty breathing. If you experience angioedema, it is important to seek medical attention immediately.
Treatment for angioedema typically involves medications to reduce swelling and prevent further episodes. In some cases, hospitalization may be necessary to monitor the condition and provide supportive care.2
If you have a history of angioedema, it is important to carry an epinephrine auto-injector (EpiPen) in case of an emergency. Epinephrine is a medication that can quickly reduce swelling and improve breathing.
Learn More About Angioedema
Angioedema, while sometimes overlooked, can present serious health risks, particularly when triggered by common medications or allergens. Understanding the causes and recognizing the symptoms early are critical steps in managing this condition effectively.
By being proactive—whether through avoiding known triggers, carrying emergency medications, or seeking prompt medical attention—you can reduce the risk of severe complications. Staying informed about the potential dangers of medications and working closely with your healthcare provider ensures that you can make decisions that prioritize your health and safety. Taking these precautions will empower you to better manage angioedema and protect your well-being.